[Intracellular immunoglobulins in lymphogranulomatosis]

Presence of heavy chains (Mu, Gamma, Alfa) of immunoglobulins in plasma cells, in plasma cell precursors and in atypical cells (Sternberg-Reed-, Hodgkin's cells and mirror image cells) was studied by immunoperoxidase technique. In 7 cases all types of the mentioned cells revealed a strongly positive IgG reaction. In 16 cases in atypical cells beside the moderately positive IgG reaction a mild reaction of IgA has also been seen. In these cases only a few plasma cell precursors (plasmoblasts,immunoblasts) have occurred. Considering the first group of patients it can be supposed that atypical cells develop from the plasma cell precursors.