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Related Experiment Videos

Solid solutions as long-acting naltrexone delivery systems.

J L Olsen

    NIDA Research Monograph
    |January 1, 1981
    PubMed
    Summary
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    Solid solutions and dispersions can alter drug solubility and release rates. Naltrexone release was prolonged by some solid formulations, but further research is needed for acceptable injectable formulations.

    Area of Science:

    • Pharmaceutical Sciences
    • Drug Delivery Systems
    • Materials Science

    Background:

    • Solid solutions and dispersions are established techniques for modifying drug solubility and release kinetics.
    • Naltrexone's therapeutic utility can be influenced by its release profile, necessitating controlled-release strategies.
    • Cholesterol esters offer potential as formulation excipients for modulating drug release.

    Purpose of the Study:

    • To investigate the potential of solid solutions and dispersions to control naltrexone release.
    • To evaluate naltrexone-cholesterol ester combinations for extended drug release.
    • To explore the feasibility of developing injectable formulations with acceptable release rates.

    Main Methods:

    • Preparation of solid solutions and dispersions of naltrexone with cholesterol esters using methods including solvent mixing, compression, and heat.

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  • In vitro evaluation of drug release rates from the prepared formulations.
  • Characterization of particle properties influencing drug release, such as surface area and composition.

    • Main Results:

    • Solid solutions and dispersions demonstrated the ability to both increase and decrease drug solubility.
    • Several naltrexone-cholesterol ester combinations showed prolonged drug release, but not to an acceptably long duration.
    • Injectable particles capable of achieving acceptable release rates were successfully produced.

    Conclusions:

    • The formulation of solid solutions and dispersions for controlled naltrexone release is complex.
    • While some prolonging of release was observed, further optimization is required for extended-release injectable products.
    • Additional research is necessary to fully understand and refine the preparation and evaluation of these complex drug delivery systems.