Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Assessment of thyroid function.

M I Surks

    Ophthalmology
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid hormones Thyroxine (T4) and Triiodothyronine (T3) levels and free T4 index (FT4-I) indicate thyroid function. Elevated TSH signifies thyroid failure, while hyperthyroidism shows increased T4/T3, with T3 thyrotoxicosis being a specific subtype.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The changing role of scintigraphy in the evaluation of thyroid nodules.

    Seminars in nuclear medicine·2000
    Same author

    Recurrent acute suppurative thyroiditis in an adult due to a fourth branchial pouch fistula.

    The Journal of clinical endocrinology and metabolism·2000
    Same author

    High-altitude cerebral edema.

    JAMA·1999
    Same author

    Maltoma of the thyroid in a man with Hashimoto's thyroiditis.

    The Journal of clinical endocrinology and metabolism·1999
    Same author

    Recognizing the faces of hypothyroidism.

    Hospital practice (1995)·1999
    Same author

    Effect of early referral to an endocrinologist on efficiency and cost of evaluation and development of treatment plan in patients with thyroid nodules.

    The Journal of clinical endocrinology and metabolism·1998

    Area of Science:

    • Endocrinology
    • Clinical Chemistry
    • Hormone Assays

    Background:

    • Thyroid hormones Thyroxine (T4) and Triiodothyronine (T3) are crucial for metabolic regulation.
    • Serum T4 and T3 exist in bound and free forms; the free fraction (free T4) best reflects hormonal activity.
    • Accurate measurement of thyroid hormones and related markers is essential for diagnosing thyroid disorders.

    Purpose of the Study:

    • To outline the diagnostic utility of measuring serum T4, T3, and free T4 index (FT4-I) in thyroid dysfunction.
    • To differentiate between primary hypothyroidism, thyroid gland failure, and hyperthyroidism.
    • To highlight the significance of TSH levels and TRH stimulation tests in diagnosing thyroid conditions.

    Main Methods:

    • Direct radioimmunoassay for serum T4 and T3 measurement.

    Related Experiment Videos

  • Direct measurement or estimation (via T3-resin uptake as FT4-I) of free T4 concentration.
  • Assessment of serum TSH levels and response to TRH stimulation.

    • Main Results:

    • Hypothyroidism is characterized by decreased T4 and FT4-I, often with elevated TSH in cases of thyroid gland failure.
    • Hyperthyroidism typically presents with increased serum T4, T3, and free T4.
    • T3 thyrotoxicosis, a subtype of hyperthyroidism, shows normal T4 with elevated T3 and an absent TSH response to TRH.

    Conclusions:

    • Serum TSH is the most sensitive indicator of thyroid gland failure.
    • Measurement of T4, T3, free T4, and TSH provides a comprehensive assessment of thyroid status.
    • TRH stimulation tests aid in diagnosing hyperthyroidism by evaluating pituitary TSH suppression.