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Updated: Aug 9, 2026
06:58
Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
Published on: June 25, 2016
Summary
Abruptly stopping long-term baclofen can cause hallucinations or seizures. Patients should gradually taper baclofen dosage to avoid these severe adverse effects.
Area of Science:
- Pharmacology
- Neurology
- Clinical Medicine
Background:
- Baclofen is a muscle relaxant commonly prescribed for spasticity.
- Long-term use of baclofen may lead to physiological dependence.
Observation:
- Three patients on long-term baclofen therapy experienced adverse events upon dose reduction.
- These events included hallucinosis and seizures.
Findings:
- Abrupt cessation or significant dose reduction of baclofen can precipitate withdrawal symptoms.
- The severity of these symptoms can range from neurological disturbances to seizures.
Implications:
- Gradual tapering of baclofen is crucial after prolonged administration to prevent withdrawal.
- Clinicians should counsel patients on proper baclofen discontinuation protocols.
- Further research into baclofen withdrawal syndromes is warranted.
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