Immunohistochemical localization of carbonic anhydrase isoenzyme C in human brain

Carbonic anhydrase isoenzymes of human brain were examined by the immunoperoxidase method. Only the catalytically highly active isoenzyme C was found in normal cerebral and cerebellar tissues, being located in a limited number of non-neuronal cells interpreted as oligodendrocytes and in myelinated nerve fibres. The enzyme was not evident in the glial cells of astrocytomas.