Extravascular hemolytic transfusion reactions due to anti-Yk(a)+Cs(a)

The literature lacks cases which document significant hemolytic transfusion reactions or which document successful transfusions of incompatible donor blood in patients who have anti-Yk(a), anti-Cs(a), or anti-Yk(a)+Cs(a). A patient who had multiple extravascular hemolytic transfusion reactions due to anti-Yk(a)+Cs(a) is herein reported. The initial reaction was on the basis of a secondary episodes involving incompatible donor units resulted in more rapid red cell destruction and finally oliguria.