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[Prethrombosis in child malnutrition]

R Jiménez, E Jiménez, L A Mora

    Archivos Latinoamericanos De Nutricion
    |December 1, 1980
    PubMed

    Insights

    Severely malnourished children show significantly lower antithrombin III levels and a flat heparin antithrombin assay curve. This indicates a prethrombotic state, consistent with high thrombosis rates in childhood malnutrition.

    Area of Science:

    • Biochemistry
    • Hematology
    • Pediatrics

    Context:

    • Childhood malnutrition is associated with increased thrombotic events.
    • Understanding the hemostatic balance in malnourished children is crucial.

    Purpose:

    • To investigate antithrombin III (AT III) levels and heparin cofactor activity in severely malnourished children.
    • To assess the prethrombotic potential in this population.

    Summary:

    • Severely malnourished children (n=30) exhibited significantly depressed AT III levels compared to normal children (n=40).
    • Heparin antithrombin assays revealed a flat curve in malnourished children, suggesting impaired heparin-antithrombin interaction.
    • These findings point towards a prethrombotic pattern in severely malnourished children.

    Impact:

    • Highlights a potential hemostatic derangement contributing to thrombosis in childhood malnutrition.
    • Suggests the need for further research into thromboprophylaxis in malnourished pediatric populations.
    • Provides evidence supporting the link between malnutrition and increased risk of blood clots in children.

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