Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Factor VIII complex activities in acute leukemia].

W Pniejnia-Olszyński, S Lopaciuk

    Acta Haematologica Polonica
    |October 1, 1980
    PubMed
    Summary

    Patients with active acute leukemia often exhibit elevated levels of factor VIII related antigen (VIIIR:AG) and associated activities. Remission in leukemia patients typically shows normalization of these factor VIII markers.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An ultrapure plasma-derived monoclonal antibody-purified factor IX concentrate (Nonafact®), results of phase III and IV clinical studies.

    Haemophilia : the official journal of the World Federation of Hemophilia·2011
    Same author

    Factor X deficiency: clinical manifestation of 102 subjects from Europe and Latin America with mutations in the factor 10 gene.

    Haemophilia : the official journal of the World Federation of Hemophilia·2006
    Same author

    Haemophilia in Poland.

    Haemophilia : the official journal of the World Federation of Hemophilia·2006
    Same author

    Consensus perspectives on surgery in haemophilia patients with inhibitors: summary statement.

    Haemophilia : the official journal of the World Federation of Hemophilia·2004
    Same author

    Clinical efficacy, safety and pharmacokinetic properties of the factor VIII concentrate Haemoctin SDH in previously treated patients with severe haemophilia A.

    Haemophilia : the official journal of the World Federation of Hemophilia·2004
    Same author

    [Inherited thrombophilia and complications of pregnancy].

    Polskie Archiwum Medycyny Wewnetrznej·2002

    Area of Science:

    • Hematology
    • Oncology
    • Clinical Biochemistry

    Context:

    • Acute leukemia is a hematological malignancy characterized by rapid proliferation of abnormal blood cells.
    • Factor VIII procoagulant activity (VIII:C), factor VIII related antigen (VIIIR:AG), and von Willebrand factor activity (VIII:WF) are crucial for hemostasis.
    • Disruptions in coagulation factors can occur in various disease states, including malignancies.

    Purpose:

    • To investigate the levels of factor VIII procoagulant activity (VIII:C), factor VIII related antigen (VIIIR:AG), and von Willebrand factor activity (VIII:WF) in patients with acute leukemia.
    • To determine if these factor VIII markers correlate with disease activity, remission status, or specific leukemia characteristics.

    Summary:

    • Thirty-seven patients with acute leukemia were assessed for factor VIII markers.
    • A significant majority (76%) of patients with active leukemia displayed elevated VIIIR:AG, often accompanied by increased VIII:C and VIII:WF.
    • In contrast, only 25% of patients in remission showed elevated VIIIR:AG, with some exhibiting high VIII:C but normal VIIIR:AG and VIII:WF.

    Impact:

    • Findings suggest that elevated factor VIII related antigen and activity are common in active acute leukemia and may normalize during remission.
    • The study indicates no clear association between these factor VIII abnormalities and leukemia subtype or white blood cell count.
    • Further research may explore the clinical significance and potential mechanisms behind these observed changes in factor VIII during acute leukemia.

    Related Experiment Videos