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Related Experiment Videos

Monoclonal rheumatoid factor (IgG lambda) its association with amyloid deposits containing lambda light chains.

G Singh, R L Myerowitz, P A Chervenick

    Archives of Pathology & Laboratory Medicine
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    This study observed a patient with monoclonal IgG lambda rheumatoid factor and systemic amyloidosis. Findings suggest amyloidogenic monoclonal immunoglobulins may function as autoantibodies.

    Area of Science:

    • Immunology
    • Pathology
    • Oncology

    Background:

    • Rheumatoid factor (RF) is an autoantibody targeting the Fc portion of IgG.
    • Monoclonal RF can be associated with autoimmune diseases and lymphoproliferative disorders.
    • Systemic amyloidosis involves the deposition of misfolded proteins in organs, leading to dysfunction.

    Observation:

    • A four-year observation of a patient with monoclonal IgG lambda RF.
    • Consistent presence of monoclonal protein in serum and lambda light chains in urine.
    • Patient succumbed to squamous-cell carcinoma of the lung; no multiple myeloma detected at autopsy.

    Findings:

    • Systemic amyloidosis was identified, predominantly affecting blood vessels across multiple organs.
    • Immunoperoxidase staining confirmed lambda light chains in both vascular and parenchymal amyloid deposits.

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  • Absence of multiple myeloma despite the presence of monoclonal immunoglobulin and amyloidosis.

    • Implications:

    • The findings support the hypothesis that certain amyloidogenic monoclonal immunoglobulins may act as autoantibodies.
    • This case highlights a potential link between monoclonal gammopathies, autoimmune phenomena, and amyloidosis.
    • Further research is warranted to elucidate the role of autoantibodies in the pathogenesis of immunoglobulin-derived amyloidosis.