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Exercise-induced bronchospasm - pathophysiology and treatment.

R J Shephard

    Canadian Journal of Applied Sport Sciences. Journal Canadien Des Sciences Appliquees Au Sport
    |September 1, 1981
    PubMed
    Summary

    Exercise-induced bronchospasm (EIB) is common in children and influenced by exercise type and intensity. Future treatments will combine beta agonists with sodium cromoglycate for prophylaxis.

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    Area of Science:

    • Sports Medicine
    • Pulmonary Medicine
    • Pediatric Medicine

    Background:

    • Exercise-induced bronchospasm (EIB) is a prevalent condition, particularly in pediatric populations.
    • Its occurrence is influenced by various factors including exercise intensity, duration, age, and sex.
    • The primary site of airway obstruction in EIB is the large airways.

    Purpose of the Study:

    • To review the practical importance, prevalence, features, pathophysiology, and therapy of exercise-induced bronchospasm.
    • To discuss the evolving therapeutic strategies for managing EIB.

    Main Methods:

    • Literature review of exercise-induced bronchospasm.
    • Analysis of factors influencing prevalence and pathophysiology.
    • Examination of historical and current therapeutic approaches.

    Main Results:

    • Symptoms of EIB typically manifest post-exercise, peaking within 10-15 minutes.
    • Pathophysiological mechanisms involve vagal reflexes, sympathetic imbalance, prostaglandin release, and mast cell sensitization.
    • Sodium cromoglycate has been a primary prophylactic measure, with selective beta-agonists (salbutamol, terbutaline) gaining acceptance.

    Conclusions:

    • The management of EIB is evolving, with a shift towards combination therapies.
    • Selective beta-agonists are increasingly sanctioned for use in athletes.
    • Future prophylaxis strategies will likely involve combinations of selective beta-agonists and sodium cromoglycate.

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