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Related Experiment Videos

Haemostatic changes in diabetic coma.

R C Paton

    Diabetologia
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Diabetic coma causes harmful blood clotting changes, including higher clotting factors and lower antithrombin III. These findings suggest a need for anticoagulant and antiplatelet drug trials to improve patient outcomes.

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    Area of Science:

    • Endocrinology
    • Hematology
    • Internal Medicine

    Background:

    • Diabetic coma, a severe complication of diabetes mellitus, is often linked to thromboembolic events.
    • Understanding the hemostatic changes during diabetic coma is crucial for managing associated risks.

    Purpose of the Study:

    • To investigate the specific hemostatic alterations in patients experiencing diabetic coma.
    • To correlate these hematological changes with the severity and type of diabetic coma (ketoacidosis vs. hyperosmolar syndrome).

    Main Methods:

    • Prospective study involving 15 patients with diabetic coma (12 ketoacidosis, 3 hyperosmolar syndrome).
    • Analysis of hemostatic parameters including factor VIII coagulant activity, factor VIII-related antigen, fibrin degradation products, partial thromboplastin time, and antithrombin III levels.

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  • Comparison of measurements during coma versus after diabetes stabilization.

    • Main Results:

    • Diabetic ketoacidosis was associated with significantly elevated factor VIII activity, factor VIII-related antigen, and fibrin degradation products.
    • Shorter partial thromboplastin time and reduced antithrombin III concentrations were observed during ketoacidosis.
    • Two of three deaths occurred in patients with hyperosmolar syndrome and showed evidence of disseminated intravascular coagulation.

    Conclusions:

    • Hemostatic changes in diabetic ketoacidosis may indicate vascular endothelial damage and intravascular fibrin deposition.
    • Disseminated intravascular coagulation is a significant risk in hyperosmolar diabetic coma.
    • Controlled clinical trials evaluating anticoagulant and antiplatelet therapies are warranted to reduce mortality and morbidity in diabetic coma.