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Related Experiment Videos

H-Y antigen in human intersexuality.

S N Ghosh, P N Shah, H M Gharpure

    Clinical Genetics
    |July 1, 1978
    PubMed
    Summary

    H-Y antigen is crucial for testis development. Its absence in XY females with pure gonadal dysgenesis prevents testicular differentiation, while its presence in other intersex conditions supports this role.

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    Area of Science:

    • Genetics
    • Endocrinology
    • Developmental Biology

    Background:

    • The H-Y antigen plays a role in mammalian sex determination.
    • Intersex conditions involve variations in sexual development.
    • Understanding the H-Y antigen's function is key to comprehending gonadal differentiation.

    Purpose of the Study:

    • To investigate the presence and significance of H-Y antigen in various intersex conditions.
    • To determine the correlation between H-Y antigen status and gonadal differentiation.
    • To clarify the role of H-Y antigen in testicular morphology and function.

    Main Methods:

    • Karyotyping using fluorescent staining and G-banding on cultured leukocytes.
    • Analysis of H-Y antigen status in intersex patients and normal controls.
    • Comparison of H-Y antigen presence with gonadal morphology and karyotype.

    Main Results:

    • H-Y antigen was negative in XY females with pure gonadal dysgenesis (PGD).
    • H-Y antigen was positive in Klinefelter's syndrome, true hermaphroditism, and male hermaphroditism.
    • Karyotypes were confirmed for all 10 intersex cases and 18 normal subjects.

    Conclusions:

    • H-Y antigen is essential for testicular morphological differentiation.
    • The absence of H-Y antigen prevents testicular development in 46,XY PGD patients.
    • H-Y antigen does not appear to influence the secretory function of the testis.

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