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Updated: Aug 10, 2026
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Retroviral Transduction of T-cell Receptors in Mouse T-cells
Published on: October 23, 2010
Specific reversal of cytolytic T lymphocyte--target cell interaction
Journal of Supramolecular Structure and Cellular Biochemistry
|January 1, 1981
Abstract:
A functional assay is described that measures the reversal of specific cytolytic T cell (CTL)-target cell binding. Binding of 51Cr-labeled P815 cells was stable in suspension but could be readily reversed by the addition of unlabeled P815 cells. The reversal of CTL-tumor cell and CTL-spleen cell binding was H-2 specific; only cells of the same H-2 type as the bound target cell could induce reversal. In all cases, tumor cells were substantially more efficient than spleen cells in inducing specific reversal.
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