Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines

Determination of LD50 values showed 3 human neuroblastoma cell lines to be 2-8-fold more sensitive to 6-hydroxydopamine (6-OHDA) than a mouse sarcoma cell line. Treatment of the cells with 6-OHDA and ascorbic acid decreased the cytotoxicity of 6-OHDA for the sarcoma cells and increased cytotoxicity for the 3 neuroblastoma cell lines.