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Behavioural changes during withdrawal from desmethylimipramine (DMI). I. Interactions with amphetamine.
Psychopharmacology
|January 1, 1981
Summary
Tricyclic antidepressant desmethylimipramine (DMI) potentiated amphetamine anorexia acutely but not chronically. Withdrawal from DMI attenuated amphetamine anorexia and enhanced locomotor effects.
Area of Science:
- Neuropharmacology
- Behavioral Neuroscience
Background:
- Tricyclic antidepressants (TCAs) like desmethylimipramine (DMI) are used to treat depression.
- Amphetamine causes anorexia and locomotor stimulation.
Purpose of the Study:
- To investigate the effects of acute and chronic desmethylimipramine (DMI) pretreatment on amphetamine-induced anorexia in rats.
- To examine the impact of DMI withdrawal on amphetamine's anorectic and stimulant effects.
Main Methods:
- Rats were pretreated with DMI acutely or chronically.
- Amphetamine was administered to assess anorexia, locomotor activity, and stereotypy.
- Withdrawal periods of 1 week, 2 weeks, or 2 months were studied.
Main Results:
- Acute DMI pretreatment potentiated amphetamine anorexia.
- Chronic DMI pretreatment did not alter amphetamine anorexia.
- Withdrawal from chronic DMI attenuated amphetamine anorexia at 2 weeks and 2 months.
- Withdrawal from chronic DMI slightly enhanced amphetamine's locomotor and stereotypy effects.
Conclusions:
- The neurochemical actions of DMI influence amphetamine's effects on appetite and locomotion.
- DMI's impact on amphetamine-induced behaviors is dependent on treatment duration and withdrawal period.