Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gestational caffeine modifies offspring behaviour in mice.

C M Sinton, J L Valatx, M Jouvet

    Psychopharmacology
    |January 1, 1981
    PubMed
    Summary

    Caffeine exposure during pregnancy in mice led to behavioral changes in offspring, including longer avoidance latencies. This suggests caffeine acts as a behavioral teratogen, impacting fetal development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Role of orexin-A in the ventrolateral preoptic area on components of total energy expenditure.

    International journal of obesity (2005)·2017
    Same author

    Transient expression of neuropeptide W in postnatal mouse hypothalamus--a putative regulator of energy homeostasis.

    Neuroscience·2015
    Same author

    GABAA receptor-mediated input change on orexin neurons following sleep deprivation in mice.

    Neuroscience·2014
    Same author

    Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression.

    Neuroscience·2008
    Same author

    Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates.

    Neuroscience·2005
    Same author

    [The ontogeny and physiology confirms the dual nature of sleep states].

    Archives italiennes de biologie·2004

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Pharmacology

    Background:

    • Caffeine is a widely consumed psychoactive substance.
    • Understanding its effects on fetal development is crucial.

    Purpose of the Study:

    • To investigate the behavioral effects of prenatal caffeine exposure in mice.
    • To determine if caffeine acts as a behavioral teratogen.

    Main Methods:

    • Pregnant mice of BALB/c and C57BR strains received caffeine (60-100 mg/kg/day) in drinking water.
    • Offspring were behaviorally tested for 6 months starting at 9 months of age.
    • Tests included passive avoidance, activity, and habituation measures.

    Main Results:

    • Caffeine-exposed offspring showed longer latencies in passive avoidance tests compared to controls.
    • Female C57BR offspring exhibited altered activity and habituation patterns.
    • Effects were observed after controlling for postnatal maternal and environmental factors.

    Conclusions:

    • Prenatal caffeine exposure directly impacts fetal neurodevelopment in mice.
    • Caffeine should be classified as a behavioral teratogen in mice.
    • These findings highlight potential risks of caffeine consumption during pregnancy.

    Related Experiment Videos