Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conditioned temperature effects using amphetamine as the unconditioned stimulus.

R Eikelboom, J Stewart

    Psychopharmacology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ovariectomy of adult rats leads to increased expression of astrocytic basic fibroblast growth factor in the ventral tegmental area and in dopaminergic projection regions of the entorhinal and prefrontal cortex.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·1999
    Same author

    Linkage disequilibrium study of markers within the pericentromeric region of the X chromosome.

    American journal of medical genetics·1999
    Same author

    Observations on the effect of abolishing analgesic abuse and reducing smoking on cancers of the kidney and bladder in New South Wales, Australia, 1972-1995.

    Cancer causes & control : CCC·1999
    Same author

    Functional activation of punch-cultured magnocellular neuroendocrine cells by glutamate receptor subtypes.

    Journal of neuroscience methods·1999
    Same author

    Functional diversity of natural IgM.

    International immunology·1999
    Same author

    Comparison of the merits of measuring equine chorionic gonadotrophin (eCG) and blood and faecal concentrations of oestrone sulphate for determining the pregnancy status of miniature horses.

    Reproduction, fertility, and development·1999

    Amphetamine injections in rats caused conditioned hyperthermia, mimicking the drug

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Drug administration can elicit conditioned responses based on environmental cues.
    • Understanding conditioned responses is crucial for studying drug effects and addiction.
    • Previous research indicated conditioned hypothermia with morphine.

    Purpose of the Study:

    • To investigate conditioned hyperthermia in rats following amphetamine administration.
    • To determine if environmental cues associated with amphetamine injections elicit a conditioned hyperthermic response.
    • To examine the temporal characteristics of conditioned hypothermia.

    Main Methods:

    • Male Wistar rats received daily intraperitoneal injections of amphetamine (1, 2, or 5 mg/kg) or saline.
    • Rectal temperature was measured in home cage, pre-injection, and injection environments.

    Related Experiment Videos

  • Conditioning procedures involved repeated drug administration in a specific environment.

    • Main Results:

    • Conditioned hyperthermia, mimicking amphetamine's unconditioned effect, was elicited by injection environment cues.
    • This conditioned response occurred during conditioning and after a drug-free period.
    • Conditioned hypothermia was observed at 10:30 h during conditioning but not at other times.

    Conclusions:

    • Environmental cues associated with amphetamine administration can elicit conditioned hyperthermia in rats.
    • The findings suggest that amphetamine can induce conditioned physiological responses similar to morphine.
    • The temporal specificity of conditioned hypothermia indicates complex regulatory mechanisms.