[Hormonal secretion dynamics in nonalcoholic drug dependence]

The hypophyseal-gonad axis was studied in patients with non-alcoholic narcomania by specific radioimmunologic methods. The subjects examined were males, at an average age of 22.5 and a duration of the disease--3.5 years. Stimulation was conducted to all the subjects examined via synthetic LH--RH in a dose of 50 mkg, the results compared with the response reaction of 20 healthy males at the same age. A statistically significant decrease of testosterone serum concentration was found as well as a preserved response reaction with stimulation. FSH level was also decreased with a statistical significance, with an altered response reaction after stimulation. LH concentration was increased with preserved type response reaction and maximum degree of increase. The results obtained indicate preserved hypophyseal reserves but decreased hypothalamus stimulation, hence reduced sexual functions in the subjects, misappropriating with narcotics.