[Hypophyseal-ovarian disorders in chronic kidney failure]

The authors studied the plasma level of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E) and progesterone (P) in 2 female patients with chronic renal insufficiency (ChRI), aged 21--42, without any genital ailments. The patients were conservatively treated. The authors found elevated plasma level of FSH and LH in the plasma of the female patients with ChRI and decreased E and P. The direct lesion of the hypophyseal-ovarial axis by uremic toxins is the reason, admitted by the authors for the hormonal dysbalance in the patients with ChRI. Similar changes are admitted to be found at the hypothalamus level as well. According to the authors the hormonal dysbalance in the female patients with ChRI is the cause for the grave changes observed in the genital cycle.