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Updated: Aug 11, 2026

Mouse Adrenal Chromaffin Cell Isolation
Published on: January 5, 2007
On the uptake of exogenous catecholamines by adrenal chromaffin cells and nerve endings
Abstract:
Light-microscopic autoradiography has revealed characteristic labelling patterns in adrenal medullary cells following the intravenous administration of different catecholamines. The uptake patterns for [3H] dopa, [3H] dopamine, [3H] noradrenaline and [3H] adrenaline ahve been compared. In all cases A cells were more active than NA cells and cells situated in the zone nearest the cortex demonstrated a markedly higher rate of uptake than central cells. It was concluded that adjacent chromaffin cells with very similar morphology may differ as much as 50 fold in their capacities to incorporate exogenous amines. The adrenergic nature of te innervation of the vessels of the adrenal cortex and capsule in the mouse was confirmed.
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