Related Experiment Videos
Comparative effects of carrageenan on systemic candidiasis and listeriosis in mice
Abstract:
Carrageenan, a toxic substance for the mononuclear phagocyte system (MPS), increase drastically the susceptibility of mice against Listeria monocytogenes challenge but induces concurrently an increasing resistance against systemic candidiasis and granulocytosis. These results corroborate the minor role played by MPS and suggest that polymorphonuclear cells play a major role in non-specific resistance of mice against systemic candidiasis.
Insights
Carrageenan exposure increases susceptibility to Listeria monocytogenes but enhances resistance to systemic candidiasis in mice. This suggests polymorphonuclear cells, not the mononuclear phagocyte system, are crucial for candidiasis resistance.
Area of Science:
- Immunology
- Microbiology
Background:
- Carrageenan is known to affect the mononuclear phagocyte system (MPS).
- The role of different immune cells in host defense against microbial infections requires further elucidation.
Purpose of the Study:
- To investigate the impact of carrageenan on host susceptibility to Listeria monocytogenes and systemic candidiasis.
- To determine the relative contributions of the mononuclear phagocyte system (MPS) and polymorphonuclear cells in non-specific immunity.
Main Methods:
- Mice were challenged with Listeria monocytogenes and Candida albicans after carrageenan administration.
- Immune cell populations, including MPS and polymorphonuclear cells, were assessed.
Main Results:
- Carrageenan significantly increased susceptibility to Listeria monocytogenes.
- Carrageenan administration led to increased resistance against systemic candidiasis and granulocytosis.
- These findings indicate a diminished role for the MPS in defense against candidiasis.
Conclusions:
- Polymorphonuclear cells play a predominant role in non-specific resistance against systemic candidiasis.
- The mononuclear phagocyte system's role in combating systemic candidiasis appears to be minor.