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Computed tomography in von Recklinghausen's disease.
Child'S Brain
|January 1, 1981
Summary
Predicting central nervous system lesions in children with von Recklinghausen's disease is challenging. This study found abnormal CT findings in 55% of children, suggesting potential future complications.
Area of Science:
- Neurology
- Pediatrics
- Radiology
Background:
- Von Recklinghausen's disease, also known as neurofibromatosis type 1, can affect the central nervous system.
- Predicting the development of CNS lesions in affected children is clinically significant.
Purpose of the Study:
- To investigate potential predictors of central nervous system lesions in children with von Recklinghausen's disease.
- To compare computed tomography (CT) findings between pediatric and adult patients with the condition.
Main Methods:
- Retrospective analysis of CT scans from 18 children and 21 adults with von Recklinghausen's disease.
- Evaluation of common CT findings, including ventricular dilatation and periventricular changes.
- Radioisotope cisternography was used in some cases to assess cerebrospinal fluid flow.
Main Results:
- Abnormal CT findings were observed in 55% of children and 85% of adults.
- The most frequent abnormality in both groups was mild ventricular dilatation without periventricular hypodensity.
- Ventricular stasis without block was noted on radioisotope cisternography in some patients.
Conclusions:
- While direct prediction remains difficult, CT findings in children with von Recklinghausen's disease may indicate an increased risk for CNS lesions.
- The prevalence of specific CT abnormalities suggests potential differences in disease manifestation between pediatric and adult populations.
- Further longitudinal studies are warranted to fully understand the prognostic value of these imaging findings.