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Trace metal abnormalities in adults during hyperalimentation.

C J McClain

    JPEN. Journal of Parenteral and Enteral Nutrition
    |September 1, 1981
    PubMed
    Summary
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    Trace metal deficiencies, including zinc and copper, are known complications of total parenteral nutrition (TPN). Regular monitoring and supplementation are recommended to prevent adverse health effects during TPN therapy.

    Area of Science:

    • Clinical Nutrition
    • Trace Element Metabolism

    Background:

    • Trace metal deficiencies are recognized complications of total parenteral nutrition (TPN).
    • These deficiencies can manifest with diverse clinical symptoms impacting patient health.

    Purpose of the Study:

    • To describe clinical abnormalities associated with trace metal deficiencies during TPN.
    • To provide recommendations for trace metal supplementation in TPN patients.

    Main Methods:

    • Review of clinical presentations of trace metal deficiencies.
    • Formulation of supplementation guidelines based on documented cases.

    Main Results:

    • Zinc deficiency presents with skin lesions, immune dysfunction, poor growth, and mental disturbances.

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  • Copper deficiency characteristically causes hematologic abnormalities like anemia and neutropenia.
  • Chromium and selenium deficiencies are less common but documented.

    • Conclusions:

    • Regular monitoring of zinc, copper, chromium, and selenium is crucial during TPN.
    • Appropriate trace metal supplementation is essential to prevent and manage deficiencies in TPN patients.