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Leukemoid reaction associated with parenteral nutrition
JPEN. Journal of Parenteral and Enteral Nutrition
|September 1, 1981
Summary
A leukemoid reaction, a blood count mimicking leukemia, can occur during parenteral nutrition. This reaction, linked to high glucose calories, resolved after discontinuing the nutrition.
Area of Science:
- Hematology
- Oncology
- Clinical Nutrition
Background:
- Leukemoid reactions can mimic leukemia in peripheral blood counts.
- Identifying the underlying causes of such reactions is crucial for accurate diagnosis and treatment.
Observation:
- A patient undergoing treatment for colon carcinoma with hepatic metastasis developed a leukemoid reaction during parenteral nutrition.
- The reaction involved an abnormal shift towards immature neutrophilic granulocytes, correlating with caloric intake.
Findings:
- Parenteral nutrition, specifically excess glucose-related calories, was identified as the likely cause of the leukemoid reaction.
- The hematological abnormalities resolved rapidly upon cessation of parenteral nutrition, with immature cells disappearing.
Implications:
- This case highlights a potential complication of parenteral nutrition, emphasizing the need for careful monitoring of hematological parameters.
- Clinicians should consider nutritional support as a potential factor in patients presenting with leukemoid reactions, especially those with malignancy.