Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The crossmatch. A brief historical perspective.

|November 1, 1981

Summary

This summary is machine-generated.

The crossmatch test, essential for blood transfusions, has evolved significantly since 1907. Key advancements include improved red blood cell typing, faster methods, and refined techniques addressing specific compatibility issues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evidence-based recommendations for the use of WBC-reduced cellular blood components.

Transfusion·2001

Same author

Pathologic, immunohistochemical, and molecular features of benign and malignant phyllodes tumors of the breast.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2001

Same author

Developments in pretransfusion testing and compatibility testing.

Transfusion·2000

Same author

Practice parameter for the recognition, management, and prevention of adverse consequences of blood transfusion. College of American Pathologists.

Archives of pathology & laboratory medicine·2000

Same author

Relationship between mammographic screening intervals and size and histology of ductal carcinoma in situ.

AJR. American journal of roentgenology·1999

Same author

Is mammography useful in screening for local recurrences in patients with TRAM flap breast reconstruction after mastectomy for multifocal DCIS?

Annals of surgical oncology·1998

Area of Science:

Transfusion Medicine
Immunology
Hematology

Background:

The crossmatch test is a critical pre-transfusion procedure to ensure compatibility between donor red blood cells and recipient serum.
Its development and refinement are crucial for preventing transfusion reactions.

Observation:

The crossmatch test has undergone continuous modification since its inception in 1907.
Significant advancements have been documented throughout its history.

Findings:

Major milestones include recognizing the importance of red blood cell typing and the matching test itself.
The evolution encompasses the development of rapid techniques, high protein, antiglobulin, and enzyme methods.
Resolution of issues concerning the minor crossmatch and the necessity of complement has been achieved.

Related Experiment Videos

Implications:

These modifications have enhanced the safety and efficacy of blood transfusions.
Understanding the historical evolution provides context for current transfusion practices.
Ongoing refinement ensures the continued reliability of pre-transfusion compatibility testing.