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The control of the adaptation of the human neonate to postnatal nutrition
Acta Chirurgica Scandinavica. Supplementum
|January 1, 1981
Insights
Hormones released during enteral feeding are crucial for neonatal adaptation after birth. These gut and pancreatic hormones drive developmental changes in the digestive system and metabolism.
Area of Science:
- Neonatal Physiology
- Gastroenterology
- Endocrinology
Background:
- Physiological systems undergo significant changes post-birth to support neonatal nutrition.
- The transition to enteral feeding is a critical event in early development.
Purpose of the Study:
- To investigate the role of gut and pancreatic hormones in neonatal adaptation.
- To explore how enteral feeding triggers developmental changes in the gut and pancreas.
Main Methods:
- Review of existing evidence on hormonal responses to enteral feeding.
- Analysis of the impact of hormones on gut structure and function.
- Examination of the relationship between pancreatic endocrine secretion and metabolism.
Main Results:
- Enteral feeding stimulates the secretion of key gut and pancreatic hormones.
- Hormonal cascades initiated by feeding are essential for gut development.
- These hormones also play a vital role in regulating intermediary metabolism.
Conclusions:
- Gut and pancreatic hormones are central to neonatal adaptation to enteral nutrition.
- Hormonal signaling is a primary driver of postnatal gastrointestinal and metabolic development.
Abstract:
Major changes occur in the function of several physiological systems after birth which enable the neonate to adapt to postnatal nutrition. It is suggested that the secretion of gut and pancreatic hormones in response to enteral feeding has a key role in triggering a cascade of developmental changes in gut structure and function, and in the relation of pancreatic endocrine secretion to intermediary metabolism. Evidence to support this hypothesis is presented.