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Related Experiment Videos

Does long-term low-dose corticosteroid therapy cause hypertension?

S H Jackson, D G Beevers, K Myers

    Clinical Science (London, England : 1979)
    |December 1, 1981
    PubMed
    Summary

    Low-dose corticosteroid therapy for asthma and rheumatoid arthritis did not significantly increase hypertension or cause mineralocorticoid excess. Pre-existing blood pressure was the primary factor influencing changes during treatment.

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    Area of Science:

    • Endocrinology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Corticosteroids, such as prednisone and prednisolone, are commonly used for inflammatory conditions.
    • Potential side effects include hypertension and mineralocorticoid excess, necessitating investigation into low-dose therapy impacts.

    Purpose of the Study:

    • To investigate the effects of low-dose prednisone or prednisolone therapy on blood pressure and biochemical parameters.
    • To determine if low-dose corticosteroid treatment is associated with hypertension or mineralocorticoid excess.

    Main Methods:

    • A cohort of 195 patients on low-dose prednisone or prednisolone therapy was studied.
    • Blood pressure, weight, serum urea, sodium, and potassium were measured before and after at least one year of therapy.

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    Main Results:

    • A rise in mean systolic and diastolic blood pressure was observed, correlating with an increased prevalence of hypertension.
    • No significant relationship was found between blood pressure changes and corticosteroid dose or therapy duration.
    • Pre-treatment blood pressure was the main determinant of blood pressure changes during therapy.
    • Slight increases in serum sodium were noted, with no changes in serum potassium or significant weight gain.

    Conclusions:

    • Low-dose corticosteroid treatment for asthma and rheumatoid arthritis does not appear to cause hypertension.
    • Biochemical profiles during low-dose therapy do not suggest mineralocorticoid excess.