A computer analysis of specific and aspecific interictal epileptic activity in man

The preliminary results are reported for a systematic computerized analysis of interictal EEG recordings from patients with different epileptic syndromes. Both interical specific epileptic activity and non-specific background EEG signals are processed by special programs. Specific achievement are: a) Automatic recognition of spikes and quantification in every channel of their temporal incidence; b) definition of morphology and temporal relationship among spikes simultaneously recorded from different cortical and subcortical structures. Non-specific achievement: a) Characterization of background pattern; b) identification, quantification and localization of pathological frequencies. The study of changes in the described parameters induced by pharmacological therapies and measured drug plasma levels, has supplied additional criteria for the evaluation of epileptic dynamics and the monitoring of optimal treatment modes.