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Human milk: Defense against infection.

L A Hanson, T Söderström

    Progress in Clinical and Biological Research
    |January 1, 1981
    PubMed
    Summary

    Breast-feeding transfers secretory IgA antibodies, crucial for infant immunity against infections. Maternal vaccination may enhance this milk-borne protection, benefiting infant health and development.

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    Area of Science:

    • Immunology
    • Pediatrics
    • Neonatal Care

    Background:

    • Neonates have underdeveloped mucosal immunity, relying on maternal antibodies.
    • Secretory Immunoglobulin A (sIgA) is vital for mucosal protection in infants.
    • Breast milk provides substantial amounts of sIgA and other immune factors like lactoferrin.

    Purpose of the Study:

    • To explore the role of secretory IgA in protecting breast-fed infants.
    • To investigate the potential of maternal vaccination to enhance infant immunity via breast milk.
    • To understand the impact of infections post-weaning on infant growth and development.

    Main Methods:

    • Review of existing literature on sIgA, breast milk composition, and infant infections.
    • Analysis of studies on maternal vaccination strategies and their effect on milk antibody levels.
    • Examination of data correlating infant infections, weaning, and nutritional status.

    Main Results:

    • Breast-feeding significantly reduces infant infection rates globally.
    • Secretory IgA in breast milk targets various neonatal pathogens.
    • Maternal vaccination is a potential strategy to boost infant sIgA levels and immunity.
    • Weaning in developing countries often leads to increased infections, impacting growth.

    Conclusions:

    • Secretory IgA transferred through breast milk is critical for neonatal mucosal immunity.
    • Maternal immunization holds promise for enhancing passive immunity in infants.
    • Preventing post-weaning infections is essential for optimal child growth and development, especially in resource-limited settings.
    Keywords:
    AntibodiesAutoimmune ResponseBiologyBreast FeedingGrowthHealthImmunityImmunizationImmunologic FactorsInfant NutritionLactationMaternal PhysiologyNutritionPhysiologyResearch Report

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