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Glycosylated hemoglobins.

S Rahbar

    Texas Reports on Biology and Medicine
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Glycosylated hemoglobins, modified hemoglobin molecules, are elevated in diabetes. These compounds are crucial for monitoring diabetes control and understanding disease complications.

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    Area of Science:

    • Biochemistry
    • Endocrinology
    • Hematology

    Background:

    • Glycosylated hemoglobins are nonenzymatically formed by glucose condensation with hemoglobin A.
    • They are minor components of red blood cells but significantly altered in diabetes.

    Purpose of the Study:

    • To review current investigations on the biochemistry, biosynthesis, and clinical implications of glycosylated hemoglobins.
    • To explore their role as indicators for diabetes mellitus control and potential correlations with complications.

    Main Methods:

    • Literature review of recent investigations.
    • Analysis of studies on glycosylation sites and mechanisms.
    • Examination of clinical data correlating glycosylated hemoglobin levels with diabetes control and complications.

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    Main Results:

    • Glycosylated hemoglobins are increased 2-3 fold in diabetic patients.
    • Major glycosylation occurs at the N-terminus of beta-chains, but other sites on alpha and beta chains are proposed.
    • Glycosylation is a nonspecific, nonenzymatic, posttranslational modification.

    Conclusions:

    • Glycosylated hemoglobins are valuable quantitative indicators for assessing diabetes mellitus control.
    • Further research is investigating their correlation with secondary disease complications.
    • The study of glycosylated hemoglobin serves as a model for similar modifications in other proteins.