[Changes in mitochondrial and microsomal electron transport as affected by o,p'-dichlorodiphenyldichloroethane]

The paper deals with the influence of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2.2-dichloroethane (o,p'-DDD, chloditane) on NADPH-dependent reduction of cytochrome c, ferricyanide, 2,6-dichlorophenolindophenol and neotetrazolium; 156 and 312 mumol o,p'-DDD was added to the dog adrenal mitochondrial and microsomal suspension. Ferricyanide reduction decreased and neotetrazolium reduction increased under the influence of o,p'-DDD. Reduction of cytochrome c was inhibited in microsomal fraction and activated in mitochondrial one. o,p'-DDD exerted no influence on 2,6-dichlorophenolindophenol reduction in the adrenal subcellular fractions. The possible mechanisms of o,p'-DDD action on the electron transport system were discussed.