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Sodium cromoglycate and provocation tests in chronic urticaria.
Annals of Allergy
|January 1, 1982
Summary
Oral sodium cromoglycate effectively protected patients with chronic urticaria from aspirin or tartrazine challenges. This study highlights sodium cromoglycate
Area of Science:
- Immunology
- Dermatology
- Pharmacology
Background:
- Chronic urticaria is a common condition often exacerbated by specific triggers like aspirin and tartrazine.
- Identifying effective treatments for aspirin- or tartrazine-induced urticaria is crucial for patient management.
Purpose of the Study:
- To evaluate the efficacy of oral sodium cromoglycate in preventing reactions to aspirin or tartrazine in patients with chronic urticaria.
Main Methods:
- A double-blind, crossover study design was employed.
- Twenty patients with chronic urticaria were challenged with aspirin or tartrazine after pre-treatment with either oral sodium cromoglycate or placebo.
- The sequential vascular response test (SVR) was used to assess the response to challenge, with a 100% or greater increase in bleeding time defined as a positive response.
Main Results:
- Eighteen out of twenty patients showed protection when pre-treated with oral sodium cromoglycate.
- Only one patient was protected by placebo.
Conclusions:
- Oral sodium cromoglycate demonstrates significant protective effects against aspirin- and tartrazine-induced chronic urticaria.
- Sodium cromoglycate represents a promising therapeutic option for managing specific trigger-exacerbated chronic urticaria.