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[Ticarcillin activity in immunodepressed mice infected with "Pseudomonas aeruginosa" (author's transl)]
Ticarcillin (TCL) activity was studied in vivo in mice immunodepressed by either cyclophosphamide (CY) or methylprednisolone (Mpd). Each type of immunodepression was evaluated by polymorphonuclear enumeration and carbon black blood clearance. Mice were infected intraperitoneally with 3 LD50 of Pseudomonas aeruginosa and then 1,000 or 1,600 mg/kg of TCL was given by subcutaneous route. Mice were treated after 15 min and 3, 18, 24 and 36 h following infection. With 1,000 mg/kg of TCL, non-immunodepressed mice were cured. Mpd-treated mice were cured by 1,600 mg/kg of TCL, while CY-treated mice were not cured by the same dose of TCL.
Ticarcillin (TCL) activity was studied in vivo in mice immunodepressed by either cyclophosphamide (CY) or methylprednisolone (Mpd). Each type of immunodepression was evaluated by polymorphonuclear enumeration and carbon black blood clearance. Mice were infected intraperitoneally with 3 LD50 of Pseudomonas aeruginosa and then 1,000 or 1,600 mg/kg of TCL was given by subcutaneous route. Mice were treated after 15 min and 3, 18, 24 and 36 h following infection. With 1,000 mg/kg of TCL, non-immunodepressed mice were cured. Mpd-treated mice were cured by 1,600 mg/kg of TCL, while CY-treated mice were not cured by the same dose of TCL.