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A mixed packing model for bone collagen.

S Lees

    Calcified Tissue International
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This study models bone collagen

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    Area of Science:

    • Biophysics
    • Materials Science
    • Biochemistry

    Background:

    • Bone collagen's hierarchical structure is crucial for its mechanical properties.
    • Understanding the molecular arrangement and hydration of collagen is key to bone biomechanics.

    Purpose of the Study:

    • To develop a superlattice model for bone collagen structure.
    • To elucidate the role of water and mineral content in collagen organization.

    Main Methods:

    • Analysis of physical properties: sonic velocity, dimensional changes, X-ray diffraction, calorimetry, dielectric constant, and composition.
    • Development of a mixed model for collagen molecular and microfibril arrangement.

    Main Results:

    • A mixed model suggests collagen molecules are in register within microfibrils, which are staggered (Hodge-Petruska scheme).

    Related Experiment Videos

  • A square packing model with 4+ molecules/microfibril fits the data, accommodating microcrystallites.
  • Macroscopic bone matrix changes correlate with collagen superlattice molecular changes.

    • Conclusions:

    • Effective diameters for dry and wet collagen molecules were determined (1.09 nm and 1.42-1.45 nm, respectively).
    • Water in bone collagen exists in distinct regimes, with a 0.16 nm thick layer.
    • Mineralized bone has less incorporated water than demineralized bone matrix.