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Related Experiment Videos

Zinc deficiency during intravenous hyperalimentation.

B Goldwasser, N Werbin, J Stadler

    Israel Journal of Medical Sciences
    |December 1, 1981
    PubMed
    Summary

    Two patients developed zinc deficiency during total parenteral nutrition (TPN). Early low serum zinc levels highlight the necessity of trace elements in long-term TPN solutions.

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    Area of Science:

    • Clinical Medicine
    • Nutritional Science
    • Biochemistry

    Background:

    • Total parenteral nutrition (TPN) is a life-support method providing nutrients intravenously.
    • Long-term TPN can disrupt nutrient absorption and balance, potentially leading to deficiencies.
    • Trace elements are essential micronutrients often omitted or underdosed in TPN formulations.

    Observation:

    • Two distinct cases of patients exhibiting clinical signs and symptoms of zinc deficiency were identified.
    • These patients were undergoing extended periods of TPN.
    • Low serum zinc levels were observed early in the course of TPN in both individuals.

    Findings:

    • The presented cases demonstrate a direct correlation between TPN and the development of zinc deficiency.
    • Analysis suggests specific factors contributing to the rapid depletion of serum zinc in these patients.
    • The findings underscore the inadequacy of standard TPN protocols in meeting zinc requirements.

    Implications:

    • Clinicians must be vigilant for zinc deficiency symptoms in patients receiving long-term TPN.
    • Routine monitoring of serum zinc levels is recommended for TPN patients.
    • TPN formulations should be supplemented with adequate trace elements, including zinc, to prevent deficiency.

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