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Reduced capillary resistance in allergic patients
Insights
A reduced capillary resistance (CR) is common in allergic children and their relatives. This simple test may aid in diagnosing allergies and identifying carriers.
Area of Science:
- Pediatrics
- Allergy Research
- Clinical Diagnostics
Background:
- Reduced capillary resistance (CR) is a potential indicator in allergic conditions.
- Understanding CR's role in allergy diagnosis is crucial.
Purpose of the Study:
- To investigate the prevalence of reduced CR in allergic children.
- To explore the utility of CR as a diagnostic tool for allergy.
- To assess the impact of corticosteroids on CR.
Main Methods:
- Assessed capillary resistance (CR) in 67 allergic children.
- Measured CR in relatives of allergic children.
- Administered prednisone to a subset of children with normal CR.
Main Results:
- 81% of allergic children exhibited reduced CR (<16 cm Hg).
- Prednisone temporarily improved CR in one patient, affecting hemorrhagic parameters.
- Reduced CR was more prevalent in symptomatic (90%) versus asymptomatic (44%) relatives.
- No correlation was found between CR and IgE levels.
Conclusions:
- Reduced CR is a significant finding in allergic children.
- CR may serve as a simple diagnostic aid for allergy.
- CR could potentially indicate an allergy carrier state in relatives.
Abstract:
Fifty four of 67 allergic children (81%) had a pathologically reduced capillary resistance (CR) of less than 16 cm Hg. Five of the 13 allergic children with normal CR were treated with corticosteroids. Prednisone improved CR in on patient for at least 24 h, and this was reflected by improvement of hemorrhagic parameters such as bleeding intensity, bleeding pattern and blood loss. There was no correlation between CR and IgE levels. 90% of the symptomatic relatives of allergic children had a reduced CR, but only 44% of asymptomatic relatives. CR presents a simple additional tool for diagnosing allergy and might give hints to the carrier state of allergy.