Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymph node excision as a simple diagnostic aid in rare lipidoses.

H Debuch, H R Wiedemann

    European Journal of Pediatrics
    |September 8, 1978
    PubMed
    Summary

    Niemann-Pick disease involves lipid accumulation. Lymph nodes showed the most lipid storage, suggesting biopsy may aid in diagnosing this lipidosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    On the subject: Incidents with sternal puncture.

    Medizinische Klinik·2010
    Same author

    Deadly lead poisoning of a 12-week-old breast child.

    Archiv fur Kinderheilkunde·2010
    Same author

    About Infant Meningitis.

    Deutsche medizinische Wochenschrift (1946)·2010
    Same author

    About infantile meningitis.

    Deutsche medizinische Wochenschrift (1946)·2010
    Same author

    Polytopic anomalies with agenesis of the lower vertebral column.

    American journal of medical genetics·1999
    Same author

    Is p57KIP2 mutation a common mechanism for Beckwith-Wiedemann syndrome or somatic overgrowth?

    Journal of medical genetics·1998

    Area of Science:

    • Biochemistry
    • Genetics
    • Pathology

    Background:

    • Niemann-Pick disease is a rare genetic disorder characterized by the accumulation of lipids in various tissues.
    • Understanding the distribution of lipid storage is crucial for diagnosis and management.

    Purpose of the Study:

    • To investigate the lipid profile in different tissues from a Niemann-Pick disease autopsy case.
    • To evaluate the potential of lymph nodes as a diagnostic target for Niemann-Pick disease.

    Main Methods:

    • Lipid analysis was performed on six different tissues obtained from an autopsy case.
    • Quantitative analysis focused on identifying and measuring stored lipids.

    Main Results:

    • Lymph nodes demonstrated the highest concentration of stored lipids compared to other investigated tissues.
    • Specific lipid types were found to be significantly elevated in the lymph nodes.

    Conclusions:

    • Lymph nodes are a primary site for lipid accumulation in Niemann-Pick disease.
    • Biopsy of lymph nodes could offer a viable method for the chemical diagnosis of this lipidosis.

    Related Experiment Videos