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Updated: Aug 14, 2026

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
Published on: March 16, 2017
Is the human trophoblast in vitro an adaptive tissue for immunological influences?
Abstract:
The role of the extra-embryonic organs (e.g. placenta) in the feto-maternal immunological interactions is not clear. Trophoblast cells of human placenta were studied in vitro in relation to their adaptive capacities under the immunological influence of allogeneic leucocytes of pregnant women. It was shown that after an 18-h interaction some trophoblastic cells were still viable, they were rich in glycoproteins and RNA, and elicited a prominent activity of some enzymes. Mitosis was often seen. The authors suppose that the trophoblast is highly adaptable to some immunological influences in vitro.
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