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Related Experiment Videos

Sterility and use patterns of multiple-dose vials.

J C Bawden, J A Jacobson, J C Jackson

    American Journal of Hospital Pharmacy
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    This study found that multiple-dose vials (MDVs) are safe for use, with contamination rates likely below 0.4%. Proper handling and storage are crucial for maintaining the microbial integrity of these essential medical supplies.

    Area of Science:

    • Microbiology
    • Hospital Pharmacy
    • Infection Control

    Background:

    • Multiple-dose vials (MDVs) are commonly used in healthcare settings.
    • Assessing the microbial contamination risk associated with MDV use is critical for patient safety.

    Purpose of the Study:

    • To investigate the viability of microorganisms within MDVs.
    • To determine the in-use contamination rate of MDVs in a hospital setting.

    Main Methods:

    • Bacteriostatic agents were added to MDVs inoculated with Escherichia coli and Pseudomonas aeruginosa.
    • Samples were tested for viable organisms at various time points (1-168 hours).
    • Opened MDVs from patient care areas and pharmacy were collected and tested for microbial contamination.

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    Main Results:

    • Bacteria were detected in deliberately contaminated MDVs within one hour of inoculation (1-100 CFU/ml).
    • No contamination was found in MDVs beyond 16 hours post-inoculation.
    • Of 928 opened MDVs collected, none showed microbial contamination, suggesting a rate < 0.4%.

    Conclusions:

    • MDVs demonstrated a low in-use contamination rate in the studied hospital environment.
    • Lidocaine, insulin, diluents, and heparin were the most common medications in collected MDVs.
    • The study highlights the need to balance the benefits of MDV use against the costs and effectiveness of control policies.