[Effect of mannitol on rCBF in canine thalamic ischemia-an experimental study (author's transl)]

We already reported in our experimental studies that mannitol acts to inhibit cerebral infarction. The purpose of this study was to investigate the efficacy of mannitol as assessed in terms of rCBF. The experiments were carried out with the thalamic infarction model in dogs, an experimental model developed and reported by us previously. The rCBF in the thalamus was measured by the initial slope method of hydrogen clearance curves. Following administration of 20% mannitol (2 g/kg) over a period of 10 minutes, slight increases in rCBF occurred during arterial occlusion. However the effect was more pronounced in mild than in severe ischemia. The length of time required for rCBF to return to its premedication level was almost 60 minutes.