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[Hydroxyapatite microcrystals in synovial mitochondria in human and experimental rheumatism]

F Delbarre, S Laoussadi, B Amor

    Comptes Rendus Des Seances De L'Academie Des Sciences. Serie III, Sciences De La Vie
    |November 16, 1981
    PubMed

    Insights

    Hydroxyapatite microcrystals in mitochondria are linked to inflammatory rheumatism like Ankylosing Spondylitis and Reiter Syndrome. This suggests mitochondrial calcium metabolism issues in certain inflammatory arthritis.

    Area of Science:

    • Biochemistry
    • Pathology
    • Rheumatology

    Context:

    • Investigates microcrystal deposition in human inflammatory rheumatism and experimental arthritis models.
    • Focuses on hydroxyapatite microcrystals within cellular structures.

    Purpose:

    • To determine the specific locations of hydroxyapatite microcrystal deposition in various inflammatory arthropathies.
    • To explore the potential role of mitochondrial abnormalities in calcium metabolism in the context of synovial inflammation.

    Summary:

    • Hydroxyapatite microcrystals were identified in mitochondria of patients with Ankylosing Spondylitis and Reiter Syndrome.
    • These microcrystals were absent in rheumatoid synovitis and chondrocalcinosis synovitis.
    • Similar mitochondrial deposition was observed in rat and rabbit experimental arthritis, distinct from lysosomal localization.

    Impact:

    • Suggests a potential link between mitochondrial calcium metabolism dysfunction and inflammatory arthritis pathogenesis.
    • Highlights the importance of cellular localization in understanding crystal-induced joint inflammation.
    • Provides insights into the distinct pathological features of different rheumatic diseases.

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