Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-A, non-B viral hepatitis.

P V Holland, H J Alter

    Human Pathology
    |December 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Non-A, non-B hepatitis is a newly identified liver disease. Transmission studies in chimpanzees confirm an infectious agent and chronic carrier state, suggesting multiple causative agents.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    HCV Infection Alters Salivary Gland Histology and Saliva Composition.

    Journal of dental research·2022
    Same author

    The case against transfusion-transmitted non-ABC hepatitis.

    Journal of internal medicine·2018
    Same author

    The natural history of acute hepatitis C: clinical presentation, laboratory findings and treatment outcomes.

    Alimentary pharmacology & therapeutics·2011
    Same author

    Hepatitis B, hepatitis C and HIV transfusion-transmitted infections in the 21st century.

    Vox sanguinis·2010
    Same author

    Does donating blood for the first time during a national emergency create a better commitment to donating again?

    Vox sanguinis·2009
    Same author

    TRALI is due to pulmonary venule damage from leucocytes with cholesterol crystal formation.

    Vox sanguinis·2009

    Area of Science:

    • Hepatology
    • Virology
    • Transfusion Medicine

    Background:

    • Non-A, non-B hepatitis is a recognized clinical entity.
    • Initially linked to transfusion-transmitted viral infections.
    • Occurs in various epidemiological settings: sporadic, endemic, and epidemic.

    Purpose of the Study:

    • To investigate the nature and transmission of non-A, non-B hepatitis.
    • To confirm the existence of an infectious agent and chronic carrier state.
    • To explore the potential for multiple causative agents.

    Main Methods:

    • Utilized electron microscopy to identify virus-like particles.
    • Employed nonspecific laboratory tests for hepatic dysfunction (e.g., alanine aminotransferase).
    • Conducted transmission studies in chimpanzees, including cross-challenge experiments.

    Related Experiment Videos

    Main Results:

    • Identified virus-like particles of varying sizes via electron microscopy.
    • Confirmed the infectious nature of non-A, non-B hepatitis through chimpanzee transmission studies.
    • Demonstrated a chronic carrier state in humans via these studies.

    Conclusions:

    • The existence of an infectious non-A, non-B hepatitis agent is confirmed.
    • Evidence supports a chronic carrier state for this hepatitis in humans.
    • Cross-challenge studies and epidemiological data suggest that multiple agents may cause non-A, non-B hepatitis.