Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Maprotiline and seizures.

B F Hoffman, R Wachsmuth

    The Journal of Clinical Psychiatry
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Maprotiline, an antidepressant, may still trigger seizures in some patients. Caution is advised when combining antidepressants with certain neuroleptics due to seizure risk.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two-staged, adaptive placebo-controlled trial (APRICOT).

    The British journal of dermatology·2021
    Same author

    The PROCLIPI international registry of early-stage mycosis fungoides identifies substantial diagnostic delay in most patients.

    The British journal of dermatology·2018
    Same author

    U.K. consensus statement on safe clinical prescribing of bexarotene for patients with cutaneous T-cell lymphoma.

    The British journal of dermatology·2012
    Same author

    Drug compliance and the psychiatric patient.

    Canadian family physician Medecin de famille canadien·2011
    Same author

    The management of neuroleptic-induced CNS effects.

    Canadian family physician Medecin de famille canadien·2011
    Same author

    Benzodiazepines: uses and abuses.

    Canadian family physician Medecin de famille canadien·2011
    Same journal

    Major Depressive Disorder and PTSD Treatment Outcome in Interpersonal Psychotherapy and Prolonged Exposure.

    The Journal of clinical psychiatry·2026
    Same journal

    Psychiatrists and Medical Aid in Dying: Entering Uncharted Waters.

    The Journal of clinical psychiatry·2026
    Same journal

    Mind and Metabolism in Crisis: US Mortality Involving Obesity and Psychiatric Disorders-Trends, Disparities, and ARIMA Projections.

    The Journal of clinical psychiatry·2026
    Same journal

    Generative AI for the Clinical Psychopharmacologist: Is It Ready for Prime Time?

    The Journal of clinical psychiatry·2026
    Same journal

    Posttrauma Benzodiazepine Use and Subsequent PTSD: A Population-Wide Analysis Following Extreme Traumatic Exposure.

    The Journal of clinical psychiatry·2026
    Same journal

    The Challenges of PTSD Prevention: Placing Benzodiazepine Use in Context.

    The Journal of clinical psychiatry·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Clinical Psychiatry

    Background:

    • Tricyclic antidepressants (TCAs) are known to lower seizure thresholds.
    • Maprotiline, a tetracyclic antidepressant, was considered to have a lower risk of inducing seizures compared to TCAs.
    • Epileptic seizures are a significant concern in psychopharmacology.

    Observation:

    • Two cases are presented where patients experienced their first epileptic seizures while receiving therapeutic doses of maprotiline.
    • These observations challenge the prior assumption of maprotiline's safety regarding seizure induction.

    Findings:

    • Maprotiline, despite its classification, can precipitate seizures in susceptible individuals.
    • Concurrent use of maprotiline or other antidepressants with aliphatic neuroleptics may increase seizure risk due to additive or synergistic effects.

    Related Experiment Videos

  • Withdrawal from central nervous system (CNS) depressants should precede antidepressant initiation.

    • Implications:

    • Clinicians should exercise caution when prescribing maprotiline, especially in patients with a history of seizures.
    • The combination of antidepressants (including newer agents) and aliphatic neuroleptics should be avoided due to potential heightened seizure risk.
    • Careful patient selection and dose titration are crucial when initiating antidepressant therapy, particularly in those predisposed to seizures.