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ATP citrate lyase in human adipose tissue
Journal of Nutritional Science and Vitaminology
|January 1, 1981
Summary
ATP citrate lyase activity in human adipose tissue is higher in individuals receiving intravenous nutrients compared to those who fasted. Nutritional status significantly impacts this enzyme
Area of Science:
- Biochemistry
- Human Physiology
- Metabolism
Background:
- ATP citrate lyase (EC. 4.1.3.8) is a key enzyme in lipogenesis.
- Its role in human adipose tissue is not fully understood.
- Nutritional status is known to affect metabolic pathways.
Purpose of the Study:
- To investigate ATP citrate lyase activity in human adipose tissue.
- To determine the influence of nutritional status on this activity.
Main Methods:
- Assay of ATP citrate lyase activity in human adipose tissue samples.
- Comparison between two groups of patients: one receiving intravenous nutrients and another that had orally taken a meal and fasted overnight.
Main Results:
- ATP citrate lyase activity was significantly higher in adipose tissue from patients receiving intravenous nutrients.
- Conversely, activity was lower in patients who had fasted after an oral meal.
Conclusions:
- Nutritional status profoundly influences ATP citrate lyase activity in human adipose tissue.
- This suggests a regulatory role of nutrient availability in lipogenic pathways.