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Trimethoprim resistance in hospitals
British Medical Journal (Clinical Research Ed.)
|March 13, 1982
Summary
Urinary tract bacterial resistance to trimethoprim varies significantly by hospital type in Finland. Turku City Hospital showed higher resistance rates than university hospitals, highlighting the need for specific hospital data in resistance studies.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Antimicrobial resistance is a growing global health concern.
- Trimethoprim and sulphamethoxazole-trimethoprim are commonly used antibiotics for urinary tract infections.
- Hospital-specific data is crucial for understanding local resistance patterns.
Purpose of the Study:
- To assess the prevalence of antibiotic resistance in urinary tract pathogens in Finnish hospitals.
- To compare resistance rates between different types of healthcare facilities.
- To evaluate the impact of trimethoprim use on resistance development.
Main Methods:
- Collection of 1561 urinary tract pathogens from three Finnish hospitals (November 1980 - April 1981).
- Agar-plate dilution method used to test resistance against trimethoprim, sulphamethoxazole-trimethoprim, sulphamethoxazole, ampicillin, and nitrofurantoin.
- Analysis of resistance patterns in common uropathogens, including Escherichia coli and Proteus mirabilis.
Main Results:
- Trimethoprim resistance (MIC > 8 mg/l) ranged from 8.6-12.2% in university hospitals (excluding Pseudomonas) and 38.3% in Turku City Hospital.
- Escherichia coli resistance to trimethoprim was 4.1-6.2% in university hospitals versus 21% in Turku City Hospital.
- Proteus mirabilis exhibited high trimethoprim resistance (29-78%), making it the most resistant species studied.
Conclusions:
- Bacterial resistance patterns differ significantly between hospital types and cannot be directly compared.
- A single hospital's data may not be representative of national resistance trends.
- After seven years of trimethoprim use, Finnish university hospital resistance levels mirrored those in a London hospital prior to its market registration.