Immunocytochemical localization of immunoglobulins in the inflammatory lesions of polymyositis
Abstract:
Biopsy material from the muscles of 40 patients with either polymyositis or dermatomyositis was examined with the immunoperoxidase method to compare the distribution of immunoglobulin (Ig)-containing cells in the inflammatory infiltrates and elsewhere in the muscle tissue. Large numbers of IgG-positive and occasional IgM-positive cells were found in the infiltrates in 23 of these biopsies in contrast to the rather sparse representation of plasma cells. It is suggested that the Ig-containing cells may either represent local B-cell differentiation and proliferation or that the cells are involved in antibody-dependent cell-mediated tissue damage.
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