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Related Experiment Video

Updated: May 5, 2026

Murine Model of Allergen Induced Asthma
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Methacholine bronchial challenge in children.

G G Shapiro, C T Furukawa, W E Pierson

    The Journal of Allergy and Clinical Immunology
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Methacholine challenge testing identified airway hyperreactivity in many young patients with respiratory symptoms. This diagnostic tool aids in managing conditions like asthma, even without wheezing.

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    Area of Science:

    • Pulmonology
    • Pediatric Respiratory Medicine

    Background:

    • Lower airways hyperreactivity is common in young individuals with respiratory complaints.
    • Normal spirometry does not exclude airway hyperreactivity.

    Purpose of the Study:

    • To evaluate methacholine sensitivity in young subjects with suspected lower airways hyperreactivity.
    • To assess the diagnostic utility of methacholine bronchoprovocation in an outpatient setting.

    Main Methods:

    • 166 young subjects with normal spirometry but suggestive symptoms underwent methacholine challenge testing.
    • Sensitivity levels were categorized as none, mild, moderate, or extreme.
    • Patient symptoms and therapeutic responses were monitored.

    Main Results:

    • 35% of subjects showed no significant methacholine sensitivity.
    • 65% exhibited varying degrees of methacholine sensitivity (mild to extreme).
    • Cough and bronchitis were common symptoms, often without wheezing.

    Conclusions:

    • Methacholine challenge is a valuable tool for diagnosing airway hyperreactivity in young patients with respiratory symptoms.
    • The test aids in guiding appropriate therapy for conditions like asthma.
    • Methacholine bronchoprovocation is a practical adjunct for managing pediatric and young adult respiratory outpatient populations.