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Related Experiment Videos

Increased alveolar-capillary membrane permeability by monocrotaline.

M Kido, T Hirose, K Tanaka

    Japanese Journal of Medicine
    |July 1, 1981
    PubMed
    Summary

    Monocrotaline and its active metabolite, pyrrole, affect lung permeability. Pyrrole rapidly increases lung water and solute absorption, while monocrotaline

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    Area of Science:

    • Toxicology
    • Pulmonary Medicine
    • Pharmacology

    Background:

    • Monocrotaline is known to cause pulmonary hypertension.
    • The precise mechanism by which monocrotaline affects lung permeability is not fully understood.

    Purpose of the Study:

    • To investigate the early effects of monocrotaline on pulmonary alveolar-capillary membrane permeability.
    • To determine the role of monocrotaline's active metabolite, pyrrole, in these effects.

    Main Methods:

    • Cardiac catheterization and extravascular lung water content measurement in rats.
    • Absorption studies using 14C-labeled compounds (mannitol, inulin).
    • Morphological observations of lung tissue.

    Main Results:

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  • A single dose of 50 mg/kg monocrotaline induced pulmonary hypertension after 4 weeks.
  • Low doses of pyrrole (3-5 mg/kg) caused rapid alveolar flooding and increased lung water within 24 hours.
  • Pyrrole accelerated the absorption of 14C-mannitol and 14C-inulin from the lungs.

    • Conclusions:

    • Monocrotaline's effects on lung permeability are delayed and milder compared to its active metabolite, pyrrole.
    • The active metabolite, pyrrole, significantly increases lung membrane porosity.
    • These findings suggest monocrotaline increases endothelial and alveolar membrane porosity via its active metabolite.