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Cholinergic innervation in neuritic plaques.

R G Struble, L C Cork, P J Whitehouse

Science (New York, N.Y.)

|April 23, 1982

Summary

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Alzheimer

Area of Science:

Neuroscience
Neuropathology

Background:

Neuritic plaque frequency correlates with dementia severity in Alzheimer's disease.
The role of cholinergic innervation in plaque pathogenesis remains unclear.

Purpose of the Study:

To investigate if neurites within plaques are partly presynaptic cholinergic axons.
To determine the relationship between cholinergic innervation and neuritic plaque evolution.

Main Methods:

Analysis of aged monkeys (4-31 years) using acetylcholinesterase, Congo red, and silver stains.
Examining plaque character and distribution in the cerebral cortex.

Main Results:

Immature and mature plaques showed high acetylcholinesterase activity.
Amyloid content increased with plaque maturation, while neurites and acetylcholinesterase decreased.

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End-stage plaques were amyloid-rich and lacked acetylcholinesterase.

Conclusions:

Cortical cholinergic innervation significantly changes during neuritic plaque pathogenesis and evolution.
Presynaptic cholinergic axons are a component of developing neuritic plaques.