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Bromocriptine therapy in oligozoospermic infertile men.

Y AinMelk, S Belisle, N Kandalaft

Archives of Andrology

|March 1, 1982

Summary

Bromocriptine showed no significant improvement in sperm count or hormone levels for infertile males with idiopathic oligozoospermia compared to placebo. The study found no added benefit of bromocriptine over placebo for treating this condition.

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Area of Science:

Reproductive Medicine
Endocrinology
Male Infertility

Background:

Idiopathic oligozoospermia is a common cause of male infertility.
Bromocriptine is a dopamine agonist sometimes used to treat hormonal imbalances affecting fertility.

Purpose of the Study:

To evaluate the efficacy of bromocriptine versus placebo in treating infertile males with idiopathic oligozoospermia.
To assess the effects of bromocriptine on sperm parameters and hormonal profiles.

Main Methods:

Prospective, randomized, double-blind, crossover study.
17 infertile males with idiopathic oligozoospermia participated.
Patients received bromocriptine (5 mg/day) or placebo for four months, followed by the alternative treatment for four months.

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Main Results:

Bromocriptine did not significantly improve sperm count or basic hormonal profiles compared to placebo.
Luteinizing hormone-releasing hormone (LHRH) stimulation showed an increase in baseline testosterone with bromocriptine.
Thyrotropin-releasing hormone (TRH) stimulation resulted in decreased prolactin levels.

Conclusions:

Bromocriptine demonstrated no significant efficacy over placebo in improving sperm parameters or hormonal profiles in idiopathic oligozoospermia.
While some hormonal changes were observed, they did not translate to improved fertility outcomes within the study's scope.